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In practice, many supervised protocols combine these approaches

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Raleigh, D

The comparator groups differed among studies, with some employing placebo controls (e.g., PIONEER-6, Gerstein 2019), others using active comparators such as sitagliptin, glimepiride, DPP-4 inhibitors, or SGLT2 inhibitors, and some utilizing standard care or intensive lifestyle interventions as the control

In this pilot study, we investigated whether patients with idiopathic primary male infertility exhibit a proteomic signature in the sperm that could potentially be used to identify mitochondrial dysfunction and treat the condition