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Gastrointestinal Side Effects: The Frequent Flier GI issues are the most commonly reported side effects of GLP-1 medicationsand theyre not subtle

Hydration is everything

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GLP-1 drugs are shifting the paradigm in the care of chronic inflammatory and autoimmune conditions

So the honest bottom line, returning to the titles premise: retatrutide has not been shown to improve insulin resistance in women diagnosed with PCOS, because it has never been studied in them

If moving to every other day doesnt make symptoms worse, that frequency is likely enough