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Ostrem, J

Kim HK, Biessels GJ, Yu MH, Hong N, Lee Y-H, Lee B-W, et al

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The liver, which is the main organ for drug metabolism, is at a particular risk of adverse effects with respect to herbal and nutraceutical agents subject to extensive hepatic biotransformation or induction/inhibition of cytochrome P450 (CYP) enzymes (212)

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As a result, exogenous L-citrulline supplementation represents an alternative to increase the amount of L-arginine provided to NOS