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The elimination strategy targeting senescent cells thus represents a promising area of research in the context of various pathologies, including cancer, cardiovascular, and neurodegenerative diseases, by targeting the very biological foundation of aging

Berberrubine, demethyleneberberine, and their corresponding glucuronides were also be produced via incubation with the liver S9 fraction, but at a slower pace than with liver microsomes (Liu et al., 2009)

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Although the immediate terminal event was respiratory failure due to pneumonia, this was merely the final step in a pathway paved by severe, untreated OSA, obesity hypoventilation, and metabolic syndrome

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Chelombitko MA, et al