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Administration timing significantly affects Sermorelin effectiveness, with bedtime dosing 30-60 minutes before sleep producing optimal results by enhancing the natural nocturnal growth hormone pulse that occurs during deep slow-wave sleep stages

This is significantly longer than peptides reconstituted in plain sterile water, which typically degrades faster without the bacteriostatic preservative

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This allows the body to adapt to delayed gastric emptying gradually

Both compounds have roughly week-long half-lives, so several weeks of clearance separates study phases

Ethics declarations Competing interests The authors declared no conflict of interest