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Although the uptake of arginine by SLC7A3 transporters does not maintain TCA cycle flux under conditions of glutamine depletion, arginine activates mTORC1 and contributes to metabolic adaptation and tumor growth 115

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ZNF143 transcription factor mediates cell survival through upregulation of the GPX1 activity in the mitochondrial respiratory dysfunction

These objective markers are more reliable than subjective assessments, which are susceptible to expectation bias

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