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Copper is a cofactor for lysyl oxidase (the enzyme that crosslinks collagen and elastin), superoxide dismutase (a critical antioxidant enzyme), and numerous other copper-dependent enzymes involved in tissue maintenance

Musallam N, Altshuler D, Merchan C, Zakhary B, Aberle C, Papadopoulos J

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The review confirmed that NNMT-mediated NAD+ depletion impairs mitochondrial function, SIRT activity (particularly SIRT1 and SIRT3), redox balance, and energy metabolism, creating conditions relevant to cardiovascular disease research models

Growth hormone deficiency and human immunodeficiency virus