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MC4R receptors are expressed in the hypothalamus, which houses the body's master clock (suprachiasmatic nucleus) and regulates sleep-wake transitions

Staying on a maintenance dose long-term has been associated with: Lower blood pressure Improved cholesterol levels Cardiovascular protection Freedom from food noise (constant food thoughts) For some patients at their goal weight, microdosing GLP-1 medication can be a helpful strategy for maintaining results, especially if weight loss continues at standard doses, and may also offer supportive cardiometabolic or inflammatory benefits beyond weight alone

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Roubenoff, R

10.1073/pnas.1523236113 267 YuanX.MaW.ChenS.WangH.ZhongC.GaoL.et al (2023)