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This anatomical advantage creates several benefits: Absorption Rate : 60-80% typical bioavailability [2] Key Advantages : Direct absorption through nasal mucosa bypasses first-pass metabolism Rich blood supply enables rapid systemic distribution Avoids degradation by digestive enzymes Creates almost immediate plasma concentration elevation The nasal cavity's permeable epithelium allows peptides to cross directly into capillaries, then travel to the heart and throughout the body

Its potential mechanisms of action may include antiplatelet aggregation, anti-inflammation, and lipid metabolism regulation, among others

To support the drug-related analyses, the researchers also accessed the DrugBank online database, downloading information on 4,865 different compounds

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