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X-ray crystallographic studies have demonstrated that copper coordination occurs through the N-terminal amino group of glycine, the deprotonated peptide nitrogen of the Gly-His bond, and the imidazole nitrogen of histidine, forming a square-planar geometry characteristic of Cu(II) complexes

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This ensures higher bioavailability, allowing more active glutathione to reach the bloodstream and skin cells, maximizing antioxidant and skin-brightening effects

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