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Cortisol, also known as the stress hormone, is produced in the adrenal glands and plays a large role in blood sugar regulation, inflammation control, energy production and usage, blood circulation, and the fight-or-flight response

Additionally, minerals like copper are involved in the production of melanin

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Recent research has demonstrated that pH levels in the TME significantly impact immune cell function, cytokine secretion, and ammonium metabolism reprogramming, which may contribute to the decreased pH value in the TME (269)

10.1371/journal.pone.0021050 PLoS One 232 Targa Dias AnastacioH.MatosinN.OoiL

Early reports suggest a few individuals experienced sleep disturbances and increased heart rate at higher doses