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5-Amino-1MQ: inhibits NNMT

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In preclinical heart failure models, NNMT enzyme inhibition markedly reduced cardiac 1-MNA (by 77.1%), improved cardiac function, reduced left ventricular hypertrophy and fibrosis, and decreased pro-inflammatory gene expression

Jumping straight to the stack skips the dose-response curve for the better-studied compound and makes it impossible to attribute outcomes or adverse events to a specific agent

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