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In December, Novo Nordisk filed for FDA approval of CagriSema, an injectable combination of GLP-1 and amylin analogues. As these therapies advance through the pipeline, they may complement or enhance current GLP1based strategies

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Chronic elevation of cortisol, leads to glutamate accumulation, excitotoxicity, and oxidative damage, underscoring its dual role in maintaining homeostasis and contributing to pathology

The key insight is not only that glutathione participates in multiple physiologic pathways, but that its value depends on context