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Persistent higher activity (neuronal excitation) caused by chronically increased extracellular glutamate, combined with higher metabolic/energy needs, could then produce a critical state potentially resulting in neuronal death

More recent studies have found that high fat diets in mice lead to increased presence of gram-negative bacteria, malonaldehyde (MDA) modified end products, and reduced defensin expression

Definitely more energy

In the absence of reliable markers, clinicians should approach extended antioxidant use with caution, particularly when OS has not been established

In order to efficiently deliver drugs into the brain with safety and precision, various non-invasive strategies to overcome BBB have been exploited

[ Google scholar ] Al-Abdullah IH, Ayala G, Panigrahi D, Kumar A M, Kumar MSA