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[71] reported that cafestol has neuroprotective effects in Drosophila models of PD, which activates the NRF2/antioxidant response element pathway, increases the expression of HO-1, eliminates excessive ROS production, protects against oxidative DNA damage, and upregulates glutathione [71,72]

This is partly because clinical trials show that it leads to significant weight loss and better metabolic health

Indrevr RL, Holm KL, Aukrust P, Osnes LT, Naderi EH, Fevang B, et al

Alternatively, high intracellular concentrations of reduced glutathione [21] could be used elute the GST-protein from the glutathione-containing material