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Ongoing investigations in our laboratory and clinical program aim to further substantiate this surprising observation in MDS and in clonal hematopoiesis of indeterminate significance (CHIP) and in clarifying the mechanism behind these effects. Further analysis of prospective cohorts with serial biospecimens would be advantageous to understand the potential connection between GLP-1 exposure and inflammasone markers and how this could influence ROS and DNA damage
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GLP-1 medications sit at the opposite, well-studied end
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