The GOT1-mediated glutamine metabolic pathway is a critical survival mechanism when the major glutamine pathway is inhibited, and it promotes tumorigenesis and development by replenishing the tricarboxylic acid (TCA) cycle, maintaining redox homeostasis, and providing the essential precursor, aspartic acid (Asp), for nucleotide production
In addition, the peaks located at 580 to 900 cm 1 indicate the enhancement of out-of-plane bending vibration of the aromatic nucleus
Even though this phenomenon has not been fully understood in the context of the possible exacerbation of pro-depressive changes by GLP-1RA administration, it certainly requires careful investigation before the potential introduction of these compounds to the clinic for the treatment of mood disorders in the future
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Glutathione detoxifies by using glutathione transferases
Administration of N -acetylcysteine reverses GSH depletion and restores ARE-associated transcriptional activity to basal levels (Limn-Pacheco et al., 2007)