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The trigeminovascular system includes both the trigeminal nerve neurons and the cerebral blood vessels

Arch Iran Med 22(4):204210 Scioli MG, DAmico F, Guzmn RR, Miranda EM, Orlandi A (2019) Oxidative stress-induced endothelial dysfunction contributes to cardiovascular disease

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The prolonged half-life ensures that therapeutic drug concentrations remain stable between doses, allowing continuous engagement with GLP-1, GIP, and glucagon receptors throughout the dosing interval

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