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Most large clinical trials excluded women actively attempting conception

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Genetic predisposition: A gene variation of the MTHFR (methylenetetrahydrofolate reductase) gene is common in Hashimotos, and results in poor methylation (ability to detoxify)

Imaging 29 , 121129 (2013)

Brain fog and concentration Many people with hypothyroidism experience cognitive difficulties, sometimes described as thyroid brain fog