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There was a significant increase in plasma and urinary creatine, and in phosphocreatine concentrations for the DCr (dietary creatine only) and CrO+D groups compared with the control group

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High-dose or prolonged pyridoxine supplementation can also lead to alterations in other nutrient levels, for example, extended use of large doses has been associated with reduced serum folate concentrations in some reports, which suggests a need to monitor nutritional balance during long-term therapy

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Always follow the dosing instructions on the label or as a healthcare provider prescribes