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[] Lead is a toxicant that accumulates in the body and has systemic effects although it typically affects both the development of the central and peripheral nervous system

Thymoquinone (TMQ) has strong anti-psoriatic efficacy, but its hydrophobicity, low water solubility, and light and pH sensitivity limit its transport to the target site

Activation of central trigeminovascular neurons by cortical spreading depression

Temporary injection site reactions, including pain, redness, or swelling, are possible