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The participant must be at least 18 years old and: Have a BMI of 35 or greater, or Have a BMI of 30 or greater with a diagnosis of diastolic heart failure, uncontrolled hypertension or chronic kidney disease Stage 3a or higher, or Have a BMI of 27 or greater with pre-diabetes, previous myocardial infarction or stroke, or symptomatic peripheral artery disease

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Cell Immunol (2010) 266(1):16

The danger with rapid weight loss is that if we drastically reduce our calorie intake and dont exercise, much of the weight we lose may come from fat and lean body masswhich includes muscle, fluid and bone mass

Regulation of body weight: Lessons learned from bariatric surgery