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In naturally aged mice, FOXO4-DRI improved the testicular microenvironment and alleviated age-related testosterone secretion insufficiency with decreased p53, p21, and p16 protein levels in treated testes compared to aged controls
detection: 0.5% 5-mC per 100 ng DNA
10.1210/endo-129-5-2799 215 TodaK.TakedaK.OkadaT.AkiraS.SaibaraT.KanameT.et al (2001)
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This review also emphasizes advancements in experimental models, including brain organoids and transgenic animals, which serve as crucial platforms for mechanistic studies and therapeutic validation
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