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SNIP1 proteins were eluted 5 times with 300 l of elution buffer (50 mM NaH 2 PO 4 , pH 8.0, 500 mM NaCl, 250 mM imidazole, 10 % glycerol, 1 % Triton X-100)

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CagriSema Phase 2 Proof-of-Concept (NCT04982575) Study Title: "Efficacy and Safety of Cagrilintide 2.4 mg in Combination With Semaglutide 2.4 mg for Weight Management" Status: Completed Phase: Phase 2 Enrollment: 92 participants Study Period: 2021-2022 Design: Randomized, double-blind, active-controlled Duration: 32 weeks Arms: CagriSema vs

Silencing CDO1 leads to suppression of erastin-induced ferroptosis in vitro and in vivo , and inhibition of CDO1 restores cellular GSA levels, which prevents ROS generation