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A Japanese case report of 3 kidney transplant recipients with metabolic syndrome that safely tolerated oral semaglutide reported that all patients experienced weight loss, 2 had decreased HbA 1c , and one had decreased albuminuria

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The remaining amount is so minuscule its considered clinically insignificant

A longitudinal study of post-approval clinical trials found that the number of newly initiated trials for small-molecule drugs dropped by 45.3% following the IRAs passage, as companies redirected capital toward biologics that offer a longer window of pricing freedom

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