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Vitamin E deficiency has also been observed in individuals with fat malabsorption syndromes (including patients with cystic fibrosis

The broader cultural context also matters

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These receptors act as cellular sensors of physical stimuli

at the intracellular level, uric acid is a compound that generates endothelial dysfunction by favoring the formation of cytokines and lipid peroxidation, reducing the amount of endothelial nitric oxide, and favoring the pro-inflammatory cascade ERK/p38 MAPK [25,26]