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Increased levels of free fatty acids and liquid droplets were detected in iPSC-derived motor neurons from C9orf72 ALS/FTD patients, suggesting the presence of dysregulated lipid metabolism by free fatty acid synthesis (Liu Y

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The functional consequence in animal models is synergistic rather than additive GH output: GHRH-R priming increases the pool of releasable GH vesicles, and GHS-R1a co-stimulation then drives a larger amplitude pulse than either receptor produces alone

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Toxicity evaluations demonstrate an IC50 above 300 g/mL for joint cells and no adverse effects in 28-day in vivo studies

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