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Elokda AS, Shields RK, Nielsen DH

This mechanism consequently reduces ROS production and inflammatory mediator release, thereby protecting neurons from oxidative damage [68,69,70]

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This effectively shuts down areas in the brain involved in feeding response, homeostatic controls, energy balance and decision-making about foodas well as the liking and wanting of food and impulsive behaviors associated with eating

These findings emphasize the need for sex-stratified clinical trials to better understand how metformin influences cognitive function in men and women