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Here are simple, sustainable strategies that can help support your stress response: Practice daily mindfulness Just 10 minutes of deep breathing, meditation, or yoga can lower cortisol and improve mental clarity

Abbreviations ASUD alcohol and other substance use disorder AUD alcohol use disorder BMI body mass index CNS central nervous system DPP-4 dipeptidyl peptidase-4 DSM-5 Diagnostic and Statistical Manual of Mental Disorders version 5 EX-4 exendin-4 FDA Food and Drug Administration GABA -aminobutyric acid GLP-1 glucagon-like peptide-1 GLP-1R glucagon-like peptide-1 receptor GLP-1RA glucagon-like peptide-1 receptor agonist NAc nucleus accumbens NRT nicotine replacement therapy NTS nucleus tractus solitarius OUD opioid use disorder PFC prefrontal cortex RCT randomized controlled trial T2DM type 2 diabetes mellitus TUD tobacco use disorder VTA ventral tegmental area Contributor Information Nirupam M Srinivasan, School of Medicine, University of Galway, Galway H91 TK33, Ireland

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You can address all of these with lifestyle changes to make sure youre resting, eating, and drinking enough

As of July 2026, the FDA has not required Novo Nordisk to add a NAION warning to Wegovys label

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