41 HT is enriched in patients with SM, 42,43 in Hymenoptera -allergic patients with severe anaphylaxis, 44,45 and in patients with idiopathic anaphylaxis
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N Engl J Med 1985;312:137-141 39
However, Er-targeted therapies are likely to worsen outcomes in carriers of the highly common PNPLA3 p.I148M variant, where ER activation may increase the number of pathogenic malfunctioning defective PNPLA3 enzymes on lipid droplets to drive liver lipid accumulation and worsen MASLD severity (47)
CRISPR/Cas enables the remodeling of crops for sustainable climate-smart agriculture and nutritional security
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