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Summary PD is commonly associated with fibrotic disorders (e.g., Dupuytrens contracture), cardiovascular diseases (e.g., hypertension, atherosclerosis), metabolic conditions (e.g., diabetes, obesity), and hormonal imbalances (e.g., low testosterone)

In intracerebral hemorrhage mouse models, the normalization of tight junction proteins ZO-1 and occludin by fibroblasts has been observed to enhance BBB integrity [293]

Tube formation assay Angiogenesis was assessed by tube formation assay