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Ferroptosis is regulated by distinct molecular pathways and was shown to play an important role in degenerative and neoplastic diseases 26

We used this age as a threshold to isolate an elder sub-group

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Some drugs having a catechol structure, used in the treatment of hypertension, asthma and Parkinson's disease, can be also O-methylated by the COMT, thus preventing the formation of toxic quinones (Vereczkey et al., 1998