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Using NMRI mice, systemic Ex4 (2.4 g/kg, i.p.) attenuated hyperlocomotion induced by cocaine (15 mg/kg, i.p.) and amphetamine (2 mg/kg, i.p.) and abolished drug-evoked increases in extracellular dopamine in the NAc, as assessed via in vivo microdialysis

132 Dehydrocostus lactone exerts different pharmacological benefits, including pro-apoptotic, 133 anti-proliferative, 134 anti-fibrotic, 135 and anti-inflammatory

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Confirmation with a repeat or second test is necessary

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Buxton ILO (2006): Pharmacokinetics and pharmacodynamics: the dynamics of drug absorption, distribution, action, and elimination