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Studies have examined how these metabolic changes affect various cellular processes including energy metabolism and gene expression

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Look for active, co-enzymated, or methylated forms (e.g., riboflavin5phosphate, methylfolate, methylcobalamin) if you have trouble converting standard forms (such as MTHFR carriers) or if you suffer from functional deficiencies (i.e., B12-related anemia despite high serum levels of B12)

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Imaging studies offer the most objective assessment but add cost and complexity