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Over five million patients are treated with TS inhibitors annually 89,90 , expanding our findings beyond the CRC field to other disease indications that use pemetrexed or methotrexate, such as lung cancer

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This Review aims to provide a comprehensive overview of SRXN1-mediated redox regulation of Cys oxidation, with a particular focus on its implications in liver disease mechanisms

Fluctuations are detrimental