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Together, these results suggest that semaglutide drives a consistent program of inflammatory resolution in non-neuronal cells that counteracts LPS-induced changes across brain regions

Same results were obtained on culture models, the P e values of ibuprofen were 0.28 and 0.53 10 6 cm/s across a porcine brain endothelial cell line and a rat primary brain endothelial based BBB models, respectively [71]

Weight Loss Reported Phase 2, NEJM 2023 48 Weeks at Highest Dose Phase 2 trial duration 3 Receptor Targets GLP-1, GIP, glucagon Not FDA-approved Regulatory Status Investigational

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Not legally at this time

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