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When dose adjustment makes sense Severe heartburn that does not respond to 4 to 6 weeks of aggressive management (dietary changes plus OTC medications) at a particular dose may warrant stepping back

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Mitochondrial products, such as acetyl CoA, -ketoglutarate, succinate, fumarate, and FAD/FADH, will induce specific and targeted chromatin modifications and change transcriptional silencing or gene expression

Curr Opin Mol Ther 12:790797 Onge EL, Miller SA (2010) Albiglutide: a new GLP-1 analog for the treatment of type 2 diabetes

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