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An additional supporting point, so far not noticed (1-3), belongs to the lower esophageal and pyloric sphincter function

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It should be stored in a freezer at or below -20 C

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Neuronal activation mapping using cFos immunostaining in the area postrema (AP), nucleus tractus solitarius (NTS), and lateral parabrachial nucleus (LPBN) provided mechanistic insight

These findings provide compelling evidence that the gut microbiota can drive systemic immune modulation, offering novel insights into hostmicrobiota crosstalk and potential therapeutic interventions