semaglutide recombinant synthesis chemical Method for preparing by biochemical method Method for preparing semaglutide by

The preparation method according to any one of claims 1 to 7, wherein for Boc-His(Trt)-OH, the coupling is performed by using a B+A+C system

The term Aib amino acid as used herein refers to 2-Aminoisobutyric acid, or a-aminoisobutyric acid or a-methylalanine or 2-methylalanine

The method is simple and convenient to operate, the sidereaction is reduced, the risk of racemization of the amino acid compound is greatly reduced, and the method has a wide application prospect and is convenient for large-scale production

Active Individuals: Performance with Protection Women combining increased physical activity with weight management need sustained muscle function alongside body composition changes

Claim 6: The process according to claim 5, which comprises: a) inducing transformant prokaryotic cells which comprise of expression vector and a nucleotide SUBSTITUTE SHEETS (RULE 26) sequence encoding Formula (II) or Formula (III) in fermentation culture medium

The cleavage enzyme can be selected from Yeast ubiquitin hydrolase (YUH1) and the like