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ROS are also created as a result of phagocytosis by the RPE of the photoreceptors light absorbing photo-pigments contained in the outer segments (OS) 24

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doi: 10.1016/j.cca.2014.01.037 161 JiangWXiangCCazacuSBrodieCMikkelsenT

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The combination can produce severe constipation that goes beyond mere discomfort into territory that affects quality of life and medication compliance