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Combination index (CI) was calculated using the CompuSyn software, CI 1.0 was defined as antagonism

It has been reported that the NAD + /NADH ratio is more important for maintaining good health than NAD + alone (138, 139)

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Moreover, focused PK studies were conducted for metronidazol, Metro-P3 and MF-03 at a dose of 7.1 mg kg 1 perorally each