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This article explains how retatrutide works, summarises current clinical evidence, outlines its safety profile, and sets out the regulatory steps required before it could become available on the NHS

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Metformin's long track record of safety and tolerability across decades makes it a stable foundation, while GLP-1 medications add weight loss benefits and cardiovascular protective effects recognized in major trials

Functional outcomes and quality of life In patients with HFpEF, the primary outcome, i.e., worsening heart failure, was assessed by assessing functional outcomes using three scales (change in KCCQ-CSS, change in 6MWD, and change in body weight), as explained in Methods section

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