Studies has demonstrated that increasing the Nrf2 levels in astrocytes inhibits apoptosis 46 and that Nrf2 translocates into the nucleus to regulate gene expression, crucial for oxidative stress and cardiac apoptosis induced by hypoxia/reperfusion (H/R) 47,48,49
N Engl J Med 383:14251435 McMurray JJV, Solomon SD, Inzucchi SE, Kber L, Kosiborod MN, Martinez FA, Ponikowski P, Sabatine MS, Anand IS, Blohlvek J, Bhm M, Chiang CE, Chopra VK, de Boer RA, Desai AS, Diez M, Drozdz J, Dukt A, Ge J, Howlett JG, Katova T, Kitakaze M, Ljungman CEA, Merkely B, Nicolau JC, OMeara E, Petrie MC, Vinh PN, Schou M, Tereshchenko S, Verma S, Held C, DeMets DL, Docherty KF, Jhund PS, Bengtsson O, Sjstrand M, Langkilde AM (2019) DAPA-HF Trial Committees and Investigators
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Therefore, maintaining the balance among these systems is essential for optimal endometrial function
ow does liposomal glutathione overcome this limitation