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Future research should also prioritize the identification and optimization of natural compounds with favorable pharmacokinetic profiles, low toxicity, and minimal risk to reproductive function

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Although an estimated 89% of households in the world now have access to iodized salt (8), mild-to-moderate iodine deficiency remains a public health concern in at least 21 countries (9)

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Rigorous on-target selectivity, in vivo durability, and immune safety profiling will be critical as these programs mature (151, 153)