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Wondering what B12 even is

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High-dose oral B12 (10002000 micrograms daily) may be effective even in some malabsorption conditions through passive diffusion

And critically for obesity research, it acts centrally: amylin binds to receptors in the area postrema and the brainstem, where it generates satiety signals that communicate to the brain that the body has had enough to eat

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Psychological Interventions for Depression in Adolescent and Adult Congenital Heart Disease. Cochrane Database of Systematic Reviews 2003, no