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VEGFR2 activation Akt phosphorylation induction of endothelial nitric oxide synthase (eNOS) NO release local vasodilation and formation of new blood vessels at the injury site

doi: 10.1007/s00018-017-2610-1 107

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Journal Of Pharmacology And Experimental Therapeutics, 301(2), 543-550

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The framing throughout reflects the compound's actual status as a research peptide of substantial laboratory interest with a well-characterized coordination chemistry, well-grounded connections to copper-dependent extracellular matrix biology, and a distinctive cosmetic-ingredient regulated use that operates under different evidentiary frameworks from pharmaceutical approval