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However, at higher doses, metformin has been found to interfere with the levels of adenine nucleotides, including adenosine diphosphate (ADP) and ATP

Abou Alaiwi S, Xie W, and Nassar AH, et al (2020) Safety and efficacy of restarting immune checkpoint inhibitors after clinically significant immune-related adverse events in metastatic renal cell carcinoma J Immunother Cancer 8 (1) e000144 PMID: 32066646 PMCID: 7057439 38

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