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3.2 Regulation of the Keap1-Nrf2 axis Nrf2, as a leucine zipper nuclear transcription factor, is strongly negatively regulated by Keap1 activity

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The Nrf2 pathway is a key player in the antioxidant response to ROS accumulation that regulates glutathione peroxidase (GSH), heme oxygenase-1, NADPH oxidase (NOX) and several other critical pathways [80]

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