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2020;105(8):e27106

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At the population level, complications from obesity rise as BMI increases [ For years, T2DM has been viewed as a chronic, progressive condition necessitating continual adjustment of pharmacotherapy, with estimates that 50% of patients will require insulin dependence within 910 years [ The discovery that glucagon-like peptide-1 (GLP-1) enhances insulin secretion in a glucose-dependent manner and suppresses glucagon release while minimizing the risk of hypoglycemia has led to the development of various structurally distinct GLP-1 receptor (GLP-1R) agonists (GLP-1RAs) with longer circulation times for the management of T2DM [Figure 1)

Oral research-planning ranges are usually higher than the subcutaneous ranges to account for lower absorption across the gut lining

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