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The substance can also cross the BBB by passive diffusion[137]

It is mainly found in the brush borders of epithelial cells of the proximal convoluted tubules in the kidney, in the small and large intestine, prostate tissue, hepatocytes, fibroblasts and in activated leukocytes [3033], preferentially cleaving peptide hormones containing a position two alanine or proline [27]

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Assess response to a very low dose first (50-75 mcg), and taper up from there

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